Monday, 19 November 2012

Low levels of LDL cholesterol increase the risk of gallstone disese

This study was published in the Journal of Hepatology 2012 Aug 21
 
Study title and authors:
Low-density lipoprotein cholesterol and risk of gallstone disease: A Mendelian randomization study and meta-analyses.
Stender S, Frikke-Schmidt R, Benn M, Nordestgaard BG, Tybjærg-Hansen A.
Department of Clinical Biochemistry, Rigshospitalet, Denmark; Copenhagen University Hospitals, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.
 
This study can be accessed at: http://www.ncbi.nlm.nih.gov/pubmed/22922093

This study investigated the association of low density lipoprotein (LDL) cholesterol levels with gallstone disease. The study included 63,051 individuals. The individuals were divided into five groups based on their LDL cholesterol levels. The highest group had 134% higher LDL cholesterol levels than the lowest group.

The study found that those with the lowest LDL cholesterol levels had a 6% increased risk of gallstone disease compared to those with the highest LDL cholesterol levels.

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