This article is a guest post from Drug Watch. DrugWatch is an online resource which details accurate and up-to-date information on prescription and over-the-counter medications and their associated side effects. This article discusses the side effects of the diabetes drug Actos.Doctors prescribe Actos (pioglitazone) to diabetes patients to control their blood sugar. Mostly used by type 2 diabetes patients, Actos reduces blood sugar by increasing the sensitivity of cells to insulin and slowing sugar production by the liver.However, the risk for Congestive Heart Failure (CHF)...
Tuesday, 31 July 2012
Monday, 30 July 2012
Increasing saturated fat consumption is associated with a decrease in death rates from heart disease
This study was published in the Journal of Clinical Epidemiology 1996 Feb;49(2):211-6Study title and authors:Relationship between dietary intake and coronary heart disease mortality: lipid research clinics prevalence follow-up study.Esrey KL, Joseph L, Grover SA.Centre For the Analysis of Cost-Effective Care, Montreal General Hospital, Quebec, Canada.This study can be accessed at: http://www.ncbi.nlm.nih.gov/pubmed/8606322This study examined the relationship between dietary intake and death from heart disease. The study included 4,546 men, aged 30 to 79, who were followed for 12 years.Regarding...
Sunday, 29 July 2012
Heart attack survivors live longer if they have high cholesterol
This study was published in the Journal of the American Geriatrics Society 2003 Jul;51(7):930-6Study title and authors:Long-term prognostic importance of total cholesterol in elderly survivors of an acute myocardial infarction: the Cooperative Cardiovascular Pilot Project.Foody JM, Wang Y, Kiefe CI, Ellerbeck EF, Gold J, Radford MJ, Krumholz HM.Section of Cardiovascular Medicine, Department of Medicine, Yale School of Medicine, New Haven, Connecticut, USA.This study can be accessed at: http://www.ncbi.nlm.nih.gov/pubmed/12834512This study sought to determine the relationship of cholesterol...
Thursday, 26 July 2012
20 year study shows that a high saturated fat diet is associated with a reduction in heart disease
This study was published in the American Journal of Epidemiology 2005 Apr 1;161(7):672-9Study title and authors:Dietary fat intake and risk of coronary heart disease in women: 20 years of follow-up of the nurses' health study.Oh K, Hu FB, Manson JE, Stampfer MJ, Willett WC.Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA.This study can be accessed at: http://www.ncbi.nlm.nih.gov/pubmed/15781956This study examined the associations of dietary fat with the risk of coronary heart disease. The study included 78,778 women who were followed for 20 years.Regarding saturated...
Wednesday, 25 July 2012
High saturated fat diet reduces the risk of developing cardiovascular diseases
This study was published in PLoS One 2012;7(2):e31637Study title and authors:Dietary fiber and saturated fat intake associations with cardiovascular disease differ by sex in the Malmö Diet and Cancer Cohort: a prospective study.Wallström P, Sonestedt E, Hlebowicz J, Ericson U, Drake I, Persson M, Gullberg B, Hedblad B, Wirfält E.Nutrition Epidemiology Research Group, Department of Clinical Sciences, Lund University, Malmö, Sweden. peter.wallstrom@med.lu.seThis study can be accessed at: http://www.ncbi.nlm.nih.gov/pubmed/22384046This study investigated the association between nutrient intake and...
Tuesday, 24 July 2012
My book now available on kindle
At long last my book Cholesterol and Saturated Fat Prevent Heart Disease is now available on kindle.Kindle US hereKindle UK hereKindle France hereKindle Germany hereKindle Italy h...
Monday, 23 July 2012
23 year study shows a high saturated fat diet is associated with a 14% decrease in deaths from heart disease
This study was published in Cardiology 1993;82(2-3):100-21Study title and authors:Factors predictive of long-term coronary heart disease mortality among 10,059 male Israeli civil servants and municipal employees. A 23-year mortality follow-up in the Israeli Ischemic Heart Disease Study.Goldbourt U, Yaari S, Medalie JH.Department of Epidemiology and Preventive Medicine, Sackler School of Medicine, Tel Aviv University, Israel.This study can be accessed at: http://www.ncbi.nlm.nih.gov/pubmed/8324774This study investigated factors that caused coronary heart disease death. The study included 10,059...
Statins increase the risk of cataract
This study was published in QJM 2003 May;96(5):337-43Study title and authors:Cataract and the use of statins: a case-control study.Smeeth L, Hubbard R, Fletcher AE.Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK. liam.smeeth@lshtm.ac.ukThis study can be accessed at: http://www.ncbi.nlm.nih.gov/pubmed/12702782The aim of the study was to assess the risk of cataracts associated with the use of statins. The study included 15,479 people with cataract and 15,479 controls without cataract.The study found that those who were exposed to statins...
Saturday, 21 July 2012
High saturated fat consumption decreases the risk of coronary heart disease by 14%
This study was published in the American Journal of Epidemiology 1984 May;119(5):667-76 Study title and authors:Ten-year incidence of coronary heart disease in the Honolulu Heart Program. Relationship to nutrient intake.McGee DL, Reed DM, Yano K, Kagan A, Tillotson J. This study can be accessed at: http://www.ncbi.nlm.nih.gov/pubmed/6720666The study investigated the association of nutrient intake to the risk of developing coronary heart disease. The study included 8,006 men, aged 45 to 68, who were followed for ten years.The study found:(a) In men under 60, those who consumed...
Statins cause a drop in energy levels and more fatigue
This paper was published in the Archives of Internal Medicine 2012 Aug 13:1-2Study title and authors:Effects of Statins on Energy and Fatigue With Exertion: Results From a Randomized Controlled Trial.Golomb BA, Evans MA, Dimsdale JE, White HL.This study can be accessed at: http://www.ncbi.nlm.nih.gov/pubmed/22688574The study investigated the impact of statins on energy or exertional fatigue. The study lasted for six months and included 1,016 subjects, (692 men 20 years or older and 324 nonprocreative women), who were allocated to receive either 20-mg simvastatin, 40-mg pravastatin...
Friday, 20 July 2012
Saturated fat lowers the risk of type 2 diabetes in older women
This study was published in Diabetes Care 2001 Sep;24(9):1528-35 Study title and authors:Dietary fat and incidence of type 2 diabetes in older Iowa women.Meyer KA, Kushi LH, Jacobs DR Jr, Folsom AR.Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA. This study can be accessed at: http://www.ncbi.nlm.nih.gov/pubmed/11522694This study examined the association between dietary fat and type 2 diabetes. The study included 35,988 women aged 55 to 69 who were followed for 11 years.With regard to saturated fat, the study found that the women who ate the...
Wednesday, 18 July 2012
An increase in carbohydrates and decrease in saturated fats leads to a rise in heart attack risk
This study was published in the American Journal of Clinical Nutrition 2010 Jun;91(6):1764-8 Study title and authors:Intake of carbohydrates compared with intake of saturated fatty acids and risk of myocardial infarction: importance of the glycemic index.Jakobsen MU, Dethlefsen C, Joensen AM, Stegger J, Tjønneland A, Schmidt EB, Overvad K.Department of Clinical Epidemiology Aarhus University Hospital, Aalborg, Denmark. muj@dce.au.dk muj@dce.au.dk This study can be accessed at: http://www.ncbi.nlm.nih.gov/pubmed/20375186The study aimed to investigate the risk of myocardial infarction (heart...
Tuesday, 17 July 2012
With only 12 weeks of statin therapy, 36% of the patients have side effects
This study was published in QJM 1999 Jul;92(7):387-94Study title and authors:Atorvastatin compared with simvastatin-based therapies in the management of severe familial hyperlipidaemias.Wierzbicki AS, Lumb PJ, Semra Y, Chik G, Christ ER, Crook MA.Department of Chemical Pathology, St Thomas' Hospital, London, UK. Anthony.Wierzbicki@ukcl.ac.ukThis study can be accessed at: http://www.ncbi.nlm.nih.gov/pubmed/10627888The study investigated the side effects caused by statin therapy (Lipitor). Patients unable to tolerate previous statin therapy were excluded from the study....
Statins adversely affect asthma
This study was published in the Annals of Allergy, Asthma and Immunology 2009 Dec;103(6):463-8Study title and authors:The effect of statin therapy on allergic patients with asthma.Ostroukhova M, Kouides RW, Friedman E.Department of Medicine, Rochester General Hospital, Rochester, New York, USA.This study can be accessed at: http://www.ncbi.nlm.nih.gov/pubmed/20084838The objective of the study was to ascertain whether statin use adversely affects asthma. The study included 24 patients who were on statin therapy and 26 controls, not on statin therapy.The study found after six months:(a) There...
Sunday, 15 July 2012
Red meat protects women from premature ovarian failure
This study was published in the International Journal of General Medicine 2012; 5: 335–338Study title and authors Premature ovarian failure risk factors in an Iranian populationAlieh Ghassemzadeh, Laya Farzadi, and Elaheh Beyhaghi1Women’s Reproductive Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran2Alzahra University Hospital, Department of Obstetrics and Gynecology, Tabriz University of Medical Sciences, Tabriz, IranCorrespondence: Laya Farzadi, Alzahra University Hospital, Artesh Ave, Tabriz, Iran, Tel +98 411 329 19130, Fax +98 411 556 6449, Email...
Saturday, 14 July 2012
After only six months of therapy with a statin (Zocor), nearly a quarter of the patients suffered from side effects
This study was published in the New Zealand Medical Journal 1991 Nov 27;104(924):493-5Study title and authors:Simvastatin and side effects.Scott RS, Lintott CJ, Wilson MJ.Princess Margaret Hospital, Christchurch.This study can be accessed at: http://www.ncbi.nlm.nih.gov/pubmed/1745460The object of the study was to investigate the side effects of simvastatin (Zocor). The study included 110 patients newly commenced on simvastatin who completed a side effects questionnaire after six months of therapy.The study found:(a) 23.6% of patients suffered side effects.(b) 13.6% of patients suffered muscle...
Friday, 13 July 2012
The deadly effects statins have on the mevalonate pathway
Our food is used by the body in a myriad of ways. One of these is the mevalonate pathway. Please refer to the mevalonate pathway diagram below that shows some of the end products (dolichols, tau proteins (not shown) , heme A, prenylated proteins (farnesylated & geranylgeranylated proteins), isopentenyl adenine, Ubiquinone, selenoproteins (not shown) and cholesterol) of the mevalonate pathway that are blocked by statins.Mevalonate PathwayFood is turned into a compound called acetyl-CoA. In the mevalonate pathway this is then eventually converted into another compound called 3-hydroxy-3-methyglutaryl...
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