This study was published in the Journal of Lipid Research 2012 Feb;53(2):266-72Study title and author:Fifty-three year follow-up of coronary heart disease versus HDL2 and other lipoproteins in Gofman's Livermore Cohort.Williams PT.Lawrence Berkeley Laboratory, Berkeley, CA 94720, USA. ptwilliams@lbl.govThis study can be accessed at: http://www.ncbi.nlm.nih.gov/pubmed/22128321This study assessed the relationship of high density lipoprotein (HDL) cholesterol levels with total death rates and heart disease death rates. The study lasted for 53 years and included 1,905 men.HDL cholesterol is...
Wednesday, 30 May 2012
Tuesday, 29 May 2012
Men with the lowest cholesterol have a three-fold increased risk of death from AIDS compared to men with the highest cholesterol
This study was published in AIDS 1997 Jun;11(7):929-30Study title and authors:Low serum cholesterol and risk of death from AIDS.Neaton JD, Wentworth DN.This study can be accessed at: http://www.ncbi.nlm.nih.gov/pubmed/9189220The study investigated the relationship of cholesterol levels, measured prior to HIV infection, with risk of death from AIDS. The study included 332,547 men aged between 35-57 who were followed for 16 years.The study found that men with the lowest cholesterol levels, below 160 mg/dL (4.2 mmol/L), had a three-fold increased risk of death from AIDS compared to men who had cholesterol...
Increase in colorectal cancer cases in statin users
This study was published in the World Journal of Gastroenterology 2011 Dec 21;17(47):5197-202Study title and authors:Statin use and the risk of colorectal cancer: a population-based case-control study.Cheng MH, Chiu HF, Ho SC, Tsai SS, Wu TN, Yang CY.Division of Pulmonary and Critical Medicine, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung 80708, Taiwan, China.This study can be accessed at: http://www.ncbi.nlm.nih.gov/pubmed/22215945The aim of the study was to investigate whether the use of statins is associated with colorectal cancer risk. The study included...
Monday, 28 May 2012
Higher cholesterol levels in both men and women are linked to a longer life
This study was published in the Journal of Internal medicineVolume 254, Issue 4, pages 353–362, October 2003Study title and authors:Total cholesterol and mortality in the elderlyE. Casiglia, A. Mazza, V. Tikhonoff, R. Scarpa, L. Schiavon, A. C. PessinaDepartment of Clinical and Experimental Medicine, University of Padova, ItalyThis study can be accessed at: http://onlinelibrary.wiley.com/doi/10.1046/j.1365-2796.2003.01200.x/fullThe objective of the study was to evaluate whether cholesterol levels are associated with death rates and to verify whether or not this is true for...
Sunday, 27 May 2012
Low vitamin D levels associated with higher rates of cardiovascular and cancer deaths
This study was published in the American Journal of Clinical Nutrition 2011 Dec;94(6):1471-8 Study title and authors:Prospective association of vitamin D concentrations with mortality in postmenopausal women: results from the Women's Health Initiative (WHI).Eaton CB, Young A, Allison MA, Robinson J, Martin LW, Kuller LH, Johnson KC, Curb JD, Van Horn L, McTiernan A, Liu S, Manson JE.Center for Primary Care and Prevention, Alpert Medical School of Brown University, Pawtucket, RI, USA. charles_eaton@mhri.org This study can be accessed at: http://www.ncbi.nlm.nih.gov/pubmed/2203022225-hydroxyvitamin...
Saturday, 26 May 2012
Patients hospitalised with a stroke with low cholesterol have a 117% increased risk of death compared to patients with high cholesterol
This study was published in the Journals of Gerontology. Series A Biological Sciencies and Medical Sciencies 2004 Mar;59(3):293-7Study title and authors:Low cholesterol levels are associated with short-term mortality in older patients with ischemic stroke.Zuliani G, Cherubini A, Atti AR, Blè A, Vavalle C, Di Todaro F, Benedetti C, Volpato S, Marinescu MG, Senin U, Fellin R.2nd Department of Internal Medicine, University of Ferrara, Italy. gzuliani@hotmail.comThis study can be accessed at: http://www.ncbi.nlm.nih.gov/pubmed/15031316 The study evaluated the association between...
Thursday, 24 May 2012
Trend of increased kidney cancer risk with statins
This study was published in Expert Opinion on Drug Safety 2012 Apr 16Study title and authors:Statin use and the risk of kidney cancer: a population-based case-control study.Chiu HF, Kuo CC, Kuo HW, Lee IM, Lee CT, Yang CY.Kaohsiung Medical University, Institute of Pharmacology, College of Medicine , Kaohsiung , Taiwan.This study can be accessed at: http://www.ncbi.nlm.nih.gov/pubmed/22502740The objective of the study was to investigate whether the use of statins was associated with kidney cancer risk. The study included 177 kidney cancer cases and 708 controls aged 50 or over.The study...
Wednesday, 23 May 2012
Men taking gemfibrozil have a 117% increase in cardiac deaths
This study was published in the Annals of Medicine 1993 Feb;25(1):41-5Study title and authors:Efficacy of gemfibrozil in dyslipidaemic subjects with suspected heart disease. An ancillary study in the Helsinki Heart Study frame population.Frick MH, Heinonen OP, Huttunen JK, Koskinen P, Mänttäri M, Manninen V.First Department of Medicine, Helsinki University Central Hospital, Finland.This study can be accessed at: http://www.ncbi.nlm.nih.gov/pubmed/8435186The study examined the effects of gemfibrozil (a cholesterol lowering drug) on death rates in male patients who had symptoms and signs...
Tuesday, 22 May 2012
Statins increase the risk of gallstone disease
This study was published in Expert Opinion on Drug Safety 2012 May;11(3):369-74Study title and authors:Statin use and the risk of gallstone disease: a population-based case-control study.Chiu HF, Chen CC, Kuo HW, Lee IM, Wu TN, Yang CY.Kaohsiung Medical University, Institute of Pharmacology, College of Medicine , Kaohsiung , Taiwan.This study can be accessed at: http://www.ncbi.nlm.nih.gov/pubmed/22243480The aim of this study was to investigate the association between the use of statins and the risk of gallstone disease. The study included 1014 gallstone disease cases and 1014...
Statin users have a 14% increased risk of melanoma
This study was published in Cancer 2012 Mar 20Study title and authors:Prospective analysis of association between use of statins and melanoma risk in the Women's Health Initiative.Jagtap D, Rosenberg CA, Martin LW, Pettinger M, Khandekar J, Lane D, Ockene I, Simon MS.Department of Oncology, Karmanos Cancer Institute, Wayne State University, Detroit, Michigan.This study can be accessed at: http://www.ncbi.nlm.nih.gov/pubmed/22434400Melanoma is the most lethal form of skin cancer. This study examined the association between statin use and the risk of melanoma. The study consisted of 119,726 postmenopausal...
Monday, 21 May 2012
Statins increase the risk of prostate cancer by 55%
This study was published in Prostate 2011 Dec;71(16):1818-24Study title and authors:Statins increase the risk of prostate cancer: a population-based case-control study.Chang CC, Ho SC, Chiu HF, Yang CY.Department of Environmental and Occupational Health, National Cheng Kung University, Tainan, Taiwan.This study can be accessed at: http://www.ncbi.nlm.nih.gov/pubmed/21480313The aim of this study was to investigate whether the use of statins was associated with prostate cancer risk. The study included 388 prostate cancer cases and 1,552 controls. All patients were aged 50 years and older.The study...
Sunday, 20 May 2012
Response to the "everyone over 50 should be on a statin story"
I have been alerted by a few people to a story emanating from the UK that everyone over the age of fifty should be prescribed statin drugs to prevent "thousands of heart attacks and strokes".The story is about an analysis of some statin trials that apparently showed that as cholesterol levels were lowered then heart disease and stroke levels were decreased. The thrust of the argument by one of the researchers, professor Colin Baigent, is that whatever your cholesterol level, reducing it further is beneficial. As anyone who reads this blog will realise,...
Higher fat diets are better than lower fat diets in the treatment of diabetes
This study was published in Diabetes Care 1994 Mar;17(3):177-82Study title and authors:The high-monounsaturated fat diet as a practical alternative for NIDDM.Campbell LV, Marmot PE, Dyer JA, Borkman M, Storlien LH.Diabetes Centre, St. Vincent's Hospital, Camperdown, Sydney, New South Wales, Australia.This study can be accessed at: http://www.ncbi.nlm.nih.gov/pubmed/8174444The objective of the study was to examine the effects in patients with type two diabetes of a home-prepared high-fat diet compared with a low-fat, high-carbohydrate diet. Ten men were included in the trial...
Friday, 18 May 2012
Cardiovascular drugs increase the risk of suicide
This study was published in the European Journal of Clinical Pharmacology 2007 Jun;63(6):591-6Study title and authors:Cardiovascular drugs and the risk of suicide: a nested case-control study.Callréus T, Agerskov Andersen U, Hallas J, Andersen M.Institute of Public Health, Research Unit of Clinical Pharmacology, University of Southern Denmark, J.B. Winsloews Vej 9A, 5000, Odense C, Denmark. tcallreus@health.sdu.dkThis paper can be accessed at: http://www.ncbi.nlm.nih.gov/pubmed/17468865This study investigated the possible association between the use of cardiovascular drugs and suicide. 743...
Thursday, 17 May 2012
Statins and fibrates are associated with an increased risk of peripheral neuropathy
This study was published at the Journal of Epidemiology and Community Health 2004 Dec;58(12):1047-51Study title and authors:Lipid lowering drugs prescription and the risk of peripheral neuropathy: an exploratory case-control study using automated databases.Corrao G, Zambon A, Bertù L, Botteri E, Leoni O, Contiero P.Dipartimento di Statistica, Università degli Studi di Milano-Bicocca, Via Bicocca degli Arcimboldi 8, Edificio U7, 20126 Milan, Italy. giovanni.corrao@unimib.itThis study can be accessed at: http://www.ncbi.nlm.nih.gov/pubmed/15547071Peripheral neuropathy describes damage...
Wednesday, 16 May 2012
Low cholesterol levels are associated with lung disease
This study was published in Circulation 2003 Mar 25;107(11):1514-9Study title and authors:Why are patients with chronic obstructive pulmonary disease at increased risk of cardiovascular diseases? The potential role of systemic inflammation in chronic obstructive pulmonary disease.Sin DD, Man SF.This study can be accessed at: http://www.ncbi.nlm.nih.gov/pubmed/12654609This study analysed the association of cholesterol levels with the severity of airflow obstruction in people with chronic obstructive pulmonary (lung) disease. The study included 6,629 people aged 50 or over.Sin notes that air...
Tuesday, 15 May 2012
Higher cholesterol levels associated with lower death rates
This study was published in the Archives of Internal Medicine 1992 Jul;152(7):1490-500Study title and authors:Serum cholesterol level and mortality findings for men screened in the Multiple Risk Factor Intervention Trial. Multiple Risk Factor Intervention Trial Research Group.Neaton JD, Blackburn H, Jacobs D, Kuller L, Lee DJ, Sherwin R, Shih J, Stamler J, Wentworth D.Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis 55414.This study can be accessed at: http://www.ncbi.nlm.nih.gov/pubmed/1627030The study investigated the relationship between cholesterol...
Transient global amnesia associated with statin intake
This paper was published in the British Medical Journal Case Reports 2009;2009. pii: bcr06.2008.0033Study title and authors:Transient global amnesia associated with statin intake.Healy D, Morgan R, Chinnaswamy S.Cardiff University, Psychological Medicine, Hergest Unit, Bangor, LL57 2PW, U K.This paper can be accessed at: http://www.ncbi.nlm.nih.gov/pubmed/21686951A 57-year-old man treated with statins developed a range of amnestic features that led to concerns he might be suicidal; however, he did not appear to have depression. His problems began after starting rosuvastatin...
Sunday, 13 May 2012
Low cholesterol levels are associated with meningococcal sepsis
This study was published in Critical Care Medicine 2005 Jul;33(7):1610-5Study title and authors:Serum lipids and disease severity in children with severe meningococcal sepsis.Vermont CL, den Brinker M, Kâkeci N, de Kleijn ED, de Rijke YB, Joosten KF, de Groot R, Hazelzet JA.Department of Pediatrics, Erasmus MC, Sophia, Rotterdam, the Netherlands.This study can be accessed at: http://www.ncbi.nlm.nih.gov/pubmed/16003070Meningococcal sepsis is where bacteria has invaded the bloodstream. This results in fever, irritability, headaches and a stiff neck. Once the bacteria is in the blood, it begins...
Rising cholesterol levels predict survival, whilst falling cholesterol levels predicts death in people who have suffered severe injuries
This study was published in Critical Care 2003 Dec;7(6):R145-53Study title and authors:Following severe injury, hypocholesterolemia improves with convalescence but persists with organ failure or onset of infection.Dunham CM, Fealk MH, Sever WE 3rd.Assistant Director, Trauma/Critical Care Services, St, Elizabeth Health Center, Youngstown, Ohio, USA. Michael_Dunham@hmis.orgThis study can be accessed at: http://www.ncbi.nlm.nih.gov/pubmed/14624689The objective of the study was to determine the association of cholesterol levels and severe traumatic injury. The study included 28 severely...
Saturday, 12 May 2012
The adverse health effects of low cholesterol
This paper was published in Beijing Da Xue Xue Bao (Journal of Peking University) 2010 Oct 18;42(5):612-5Study title and authors:Primary and secondary hypocholesterolemiaSong JX, Ren JY, Chen H.Department of Cardiology, Peking University People's Hospital, Beijing 100044, China.This study can be accessed at: http://www.ncbi.nlm.nih.gov/pubmed/20957025In this review of the literature Song examines the influence of low cholesterol levels (hypocholesterolemia) on health.He found:(a) Low cholesterol levels are common in the population.(b) Physicians pay little attention to the...
Friday, 11 May 2012
Low cholesterol is associated with higher death rates in hospital patients
This study was published in the Annals of Clinical Biochemistry 1999 Sep;36 ( Pt 5):613-6Study title and authors:Hypocholesterolaemia in a hospital population.Crook MA, Velauthar U, Moran L, Griffiths W.Department of Chemical Pathology, Lewisham Hospital, London, UK.This study can be accessed at: http://www.ncbi.nlm.nih.gov/pubmed/10505211The study examined the effects of low cholesterol in patients admitted to a hospital. 57 patients, average age 53, with various conditions and diseases were identified with cholesterol levels less than 3.0 mmol/L (116 mg/dL).The study found:(a) 18%...
Wednesday, 9 May 2012
Low cholesterol levels associated with fatigue and depression
This study was published in the Journal of Psychosomatic Research 2002 Feb;52(2):61-3Study title and authors:Cholesterol and mood states at 3 days after delivery.Nasta MT, Grussu P, Quatraro RM, Cerutti R, Grella PV.Institute of Obstetrics and Gynaecology, University of Padua, Padua, Italy.This study can be accessed at: http://www.ncbi.nlm.nih.gov/pubmed/11832250The aim of the study was to investigate the relationship between cholesterol and mood states in women immediately following childbirth. The study included 72 women who had their mood analysed and cholesterol levels measured three...
Aspirin use is associated with a significantly increased risk of pancreatic cancer
This study was published in the Journal of the National Cancer Institute 2004 Jan 7;96(1):22-8Study title and authors:A prospective study of aspirin use and the risk of pancreatic cancer in women.Schernhammer ES, Kang JH, Chan AT, Michaud DS, Skinner HG, Giovannucci E, Colditz GA, Fuchs CS.Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. eva.schernhammer@channing.harvard.eduThis study can be accessed at: http://www.ncbi.nlm.nih.gov/pubmed/14709735The study examined the relationship between aspirin use and...
Monday, 7 May 2012
Low cholesterol levels are associated with poor memory
This study was published in Arteriosclerosis, Thrombosis, and Vascular Biology 2008 Aug;28(8):1556-62Study title and authors:Low HDL cholesterol is a risk factor for deficit and decline in memory in midlife: the Whitehall II study.Singh-Manoux A, Gimeno D, Kivimaki M, Brunner E, Marmot MG.INSERM U687-IFR69, Hôpital Paul Brousse, Bât 15/16, 16 Avenue Paul Vaillant Couturier, 94807 Villejuif Cedex, France. Archana.Singh-Manoux@inserm.frThis study can be accessed at: http://www.ncbi.nlm.nih.gov/pubmed/18591462The study investigated the association of cholesterol levels with memory. 3,673 male...
Sunday, 6 May 2012
High cholesterol levels lead to a longer life in very old people
This study was published in the Journal of Aging and Health 1996 May;8(2):220-37Study title and authors:Survival in the oldest old: death risk factors in old and very old subjects.Dontas AS, Toupadaki N, Tzonou A, Kasviki-Charvati P.Center of Studies of Age-Related Changes in Man.This study can be accessed at: http://www.ncbi.nlm.nih.gov/pubmed/10160559This study investigated which factors predict survival in the ninth decade of life. The study included 210 subjects aged 68 to 79 and 287 subjects aged over 80.Hematocrit is a measurement of how much space in the blood is...
Analysis of 519,643 people reveals low cholesterol increases the risk of dying from pancreatic cancer by 27%
This study was published in Cancer Epidemiology, Biomarkers and Prevention 2006 Dec;15(12):2435-40 Study title and authors:The effect of modifiable risk factors on pancreatic cancer mortality in populations of the Asia-Pacific region.Ansary-Moghaddam A, Huxley R, Barzi F, Lawes C, Ohkubo T, Fang X, Jee SH, Woodward M; Asia Pacific Cohort Studies Collaboration.The George Institute, University of Sydney, Australia. This study can be accessed at: http://www.ncbi.nlm.nih.gov/pubmed/17164367This analysis of 30 studies assessed the connection between cholesterol levels and death...
Friday, 4 May 2012
Low cholesterol levels linked with Crohn's disease and ulcerative colitis
This study was published in Metabolism 2006 Jul;55(7):980-8Study title and authors:Altered lipid, apolipoprotein, and lipoprotein profiles in inflammatory bowel disease: consequences on the cholesterol efflux capacity of serum using Fu5AH cell system.Ripollés Piquer B, Nazih H, Bourreille A, Segain JP, Huvelin JM, Galmiche JP, Bard JM.Laboratoire de Biochimie Générale et Appliquée, UFR de Pharmacie, Université de Nantes, 44035 Nantes, France.This study can be accessed at: http://www.ncbi.nlm.nih.gov/pubmed/16784973This study examined the association of cholesterol levels with inflammatory bowel...
Thursday, 3 May 2012
Low cholesterol is significantly associated with schizophrenia
This study was published in Acta Psychiatrica Scandinavica 2003 Sep;108(3):208-14Study title and authors:Serum leptin and cholesterol levels in schizophrenic patients with and without suicide attempts.Atmaca M, Kuloglu M, Tezcan E, Ustundag B.Departments of Psychiatry and Clinical Biochemistry, Firat University, School of Medicine, Elazig, Turkey. matmaca_p@yahoo.comThis study can be accessed at: http://www.ncbi.nlm.nih.gov/pubmed/12890276The study examined the association of cholesterol levels in schizophrenic patients with and without suicide attempts. The study included 16 medication-free...
Wednesday, 2 May 2012
High cholesterol levels are linked to a longer life
This paper was published in Circulation 1992 Sep;86(3):1046-60Study title and authors:Report of the Conference on Low Blood Cholesterol: Mortality Associations.Jacobs D, Blackburn H, Higgins M, Reed D, Iso H, McMillan G, Neaton J, Nelson J, Potter J, Rifkind B, et al.This study can be accessed at: http://www.ncbi.nlm.nih.gov/pubmed/1355411This paper featured an analysis of 18 studies that compared cholesterol levels with death rates. The studies lasted between 9 and 30 years and included 172,760 men and 124,814 women.The analysis found:(a) Women with the highest cholesterol...
People with low cholesterol are more prone to coughs, colds, runny noses and sore throats
This study was published in the American Journal of Preventive Medicine 1992 Mar-Apr;8(2):100-3Study title and authors:Effect of minor illness on serum cholesterol level.Hyman DJ, Barrett DC, Fortmann SP.Stanford Center for Research in Disease Prevention, Stanford University, Palo Alto, California 94304-1885.This study can be accessed at: http://www.ncbi.nlm.nih.gov/pubmed/1599716This study investigated the association of cholesterol levels with a minor illness. The study included 6,880 people who had their cholesterol levels measured. Additionally a further 162 people were followed...
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